IPLab:Lab 12:Radiation Changes - Revision history

Seung Park at 16:37, 3 January 2014

2014-01-03T16:37:36Z

Seung Park: /* Images */

2013-08-30T01:48:17Z

‎Images

Seung Park: /* Related IPLab Cases */

2013-08-26T15:12:13Z

‎Related IPLab Cases

Seung Park: /* Reference */

2013-08-26T15:12:04Z

‎Reference

Seung Park: /* Journal Articles */

2013-08-26T15:10:57Z

‎Journal Articles

Seung Park: /* Images */

2013-08-26T15:10:15Z

‎Images

Seung Park at 04:27, 23 August 2013

2013-08-23T04:27:00Z

Seung Park at 16:27, 21 August 2013

2013-08-21T16:27:24Z

Seung Park at 14:43, 21 August 2013

2013-08-21T14:43:46Z

Seung Park: Created page with "== Images == File:IPLab12RadiationChanges1.jpg|This is a low-power photomicrograph of the surgical specimen of the ileum. The normal i..."

2013-08-21T05:30:09Z

Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab12RadiationChanges1.jpg|This is a low-power photomicrograph of the surgical specimen of the ileum. The normal i..."

New page

== Images ==
<gallery heights="250px" widths="250px">
File:IPLab12RadiationChanges1.jpg|This is a low-power photomicrograph of the surgical specimen of the ileum. The normal ileum is to the left (1). The area of stricture consists of dense fibrous connective tissue (2) and there is loss or marked atrophy of the epithelium (3).
File:IPLab12RadiationChanges2.jpg|This is a higher-power photomicrograph of the surgical specimen of the ileum showing the transition from the normal epithelium (1) to the atrophied epithelium (2) in the area of radiation injury.
File:IPLab12RadiationChanges3.jpg|This is a higher-power photomicrograph showing the atrophied epithelium in the area of radiation injury. There are some epithelial cells deep within the mucosa (1). Note the dense fibrous connective tissue (2) within the wall of the ileum.
File:IPLab12RadiationChanges4.jpg|This is a high-power photomicrograph showing the atrophied epithelium in the area of radiation injury (1). Note the dense fibrous connective tissue within the wall of the ileum and the congested blood vessels (2).
File:IPLab12RadiationChanges5.jpg|This is a high-power photomicrograph of the wall of the ileum showing a blood vessel that has suffered radiation-induced damage and is completely occluded (arrows).
File:IPLab12RadiationChanges6.jpg|This high-power photomicrograph of the wall of the ileum shows areas of fibrosis (1), inflammatory cells (2), and abnormal pleomorphic cells (3) in the area of radiation injury. The abnormal morphology of these cells is radiation-induced. These cells are often difficult to distinguish from recurrent tumor cells.
File:IPLab12RadiationChanges7.jpg|This high-power photomicrograph of the wall of the ileum shows more examples of pleomorphic cells (arrows) due to radiation injury.
File:IPLab12RadiationChanges8.jpg|This high-power photomicrograph of the wall of the ileum shows more examples of pleomorphic cells caused by radiation injury (arrows).
</gallery>

{{IPLab 12}}

[[Category: IPLab:Lab 12]]

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/56-radiation PEIR Digital Library: Radiation Images]
+* [{{SERVER}}/library/index.php?/tags/56-radiation PEIR Digital Library: Radiation Images]
 * [http://library.med.utah.edu/WebPath/GIHTML/GIIDX.html#5 WebPath: Small Intestine Images]

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 * [http://peir.path.uab.edu/library/index.php?/tags/56-radiation PEIR Digital Library: Radiation Images]
 * [http://library.med.utah.edu/WebPath/GIHTML/GIIDX.html#5 WebPath: Small Intestine Images]
 {{IPLab 12}}
 [[Category: IPLab:Lab 12]]

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/180084-overview eMedicine Medical Library: Intestinal Radiation Injury]
 === Journal Articles ===

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 === Journal Articles ===
+* Reis ED, Vine AJ, Heimann T.  [http://www.ncbi.nlm.nih.gov/pubmed/12780647 Radiation damage to the rectum and anus: pathophysiology, clinical features and surgical implications].  ''Colorectal Dis'' 2002 Jan;4(1):2-12.
 === Images ===

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 === Images ===
+* [http://peir.path.uab.edu/library/index.php?/tags/56-radiation PEIR Digital Library: Radiation Images]
 == Related IPLab Cases ==

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 File:IPLab12RadiationChanges8.jpg|This high-power photomicrograph of the wall of the ileum shows more examples of pleomorphic cells caused by radiation injury (arrows).
 </gallery>
 == Study Questions ==

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 * <spoiler text="Why are the small intestine and colon so susceptible to radiation injury?">The gastrointestinal tract is very radiosensitive and is frequently affected in all forms of deep radiation. The intestinal epithelium (crypt cells) are particularly radiosensitive due to their high turnover rate. These cell often show nuclear and cellular pleomorphism, mitotic abnormalities, and cell necrosis. Later, ulcerations may appear, along with vascular and connective tissue changes. The late effects of intestinal injury comprise mucosal and submucosal atrophy and fibrosis, occasionally producing intestinal strictures.</spoiler>
 * <spoiler text="Are patients who have been treated with radiation more susceptible to formation of new cancers?">Yes, due to the above-mentioned alterations in nuclear and mitotic activity.</spoiler>
 {{IPLab 12}}
 [[Category: IPLab:Lab 12]]

← Older revision		Revision as of 14:43, 21 August 2013
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		+	== Clinical Summary ==
		+	This 46-year-old white female was found to have prolapse of the uterus two years earlier for which a vaginal hysterectomy had been performed. Study of the specimen demonstrated invasive squamous cell carcinoma of the cervix. Subsequently, she underwent a radical parametrectomy, removal of both tubes and ovaries, and partial resection of the bladder. Six months later, a recurrence of the tumor was treated by 6000 rads to the whole pelvis. Subsequently, the patient developed intermittent small bowel obstruction which resulted in the resection of a segment of ileum. She did well following surgery.
		+
		+	== Autopsy Findings ==
		+	The surgical specimen consisted of a 13-cm segment of ileum having a luminal circumference of 5 cm. There was a full-thickness tear measuring 2.5 cm in the center of the specimen. On opening the bowel, the mucosa was ulcerated and showed a perforation.
		+
	== Images ==		== Images ==
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">