IPLab:Lab 4:Chronic Passive Congestion - Revision history

Peter Anderson: /* Virtual Microscopy */

2015-09-16T19:17:48Z

‎Virtual Microscopy

Seung Park at 16:11, 3 January 2014

2014-01-03T16:11:10Z

Seung Park: /* Images */

2013-08-30T01:30:43Z

‎Images

Seung Park at 02:37, 22 August 2013

2013-08-22T02:37:00Z

Seung Park at 14:54, 21 August 2013

2013-08-21T14:54:41Z

Peter Anderson at 14:27, 21 August 2013

2013-08-21T14:27:17Z

Peter Anderson at 14:26, 21 August 2013

2013-08-21T14:26:58Z

Seung Park: Created page with "== Images == File:IPLab4ChronicPassiveCongestion1.jpg|This is a gross photograph of a liver demonstrating chronic passive congestion. ..."

2013-08-19T16:22:30Z

Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab4ChronicPassiveCongestion1.jpg|This is a gross photograph of a liver demonstrating chronic passive congestion. ..."

New page

== Images ==
<gallery heights="250px" widths="250px">
File:IPLab4ChronicPassiveCongestion1.jpg|This is a gross photograph of a liver demonstrating chronic passive congestion. Note the accentuation of the centrilobular pattern evidenced by the dark-brown-staining areas in this tissue.
File:IPLab4ChronicPassiveCongestion2.jpg|This is a closer view of a cut section of liver demonstrating the pattern of chronic passive congestion. The central vein regions are red and the surrounding hepatic tissue is pale tan-brown.
File:IPLab4ChronicPassiveCongestion3.jpg|This low-power photomicrograph of liver demonstrates a slightly visible pattern of centrilobular congestion at this magnification.
File:IPLab4ChronicPassiveCongestion4.jpg|This is a higher-power photomicrograph of liver demonstrating an accentuated lobular pattern with a dark red stain surrounding the central veins in the liver lobules (arrows).
File:IPLab4ChronicPassiveCongestion5.jpg|This higher-power photomicrograph of the liver lobules shows congestion and red blood cell accumulation in the sinusoidal spaces around the central vein. Note that around the portal triads (arrows) the liver cells are quite normal and there is no evidence of congestion.
File:IPLab4ChronicPassiveCongestion6.jpg|This is a high-power photomicrograph of the central vein illustrating congestion and some loss of liver parenchymal cells. A mild increase in connective tissue around the central vein is evident in this section.
File:IPLab4ChronicPassiveCongestion7.jpg|This is a high-power photomicrograph of liver with several macrophages that are distended with a brown pigment (arrow). These resident macrophages (Kupffer cells) are part of the reticuloendothelial system and normally line the sinusoidal spaces in the liver where they phagocytose the RBCs that pool, and eventually die, in the central vein region.
File:IPLab4ChronicPassiveCongestion8.jpg|This is a gross photograph of a nutmeg. You can see from the appearance of the cut surface of the nutmeg (arrow) why chronic passive congestion of the liver is sometimes referred to as "nutmeg liver."
File:IPLab4ChronicPassiveCongestion9.jpg|This is a gross photograph of the cut surface of a liver with chronic passive congestion (left) compared to the cut surface of a nutmeg (right).
</gallery>

{{IPLab 4}}

[[Category: IPLab:Lab 4]]

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 == Virtual Microscopy ==
 <peir-vm>IPLab4ChronicPassiveCongestion</peir-vm>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/672-chronic_passive_congestion PEIR Digital Library: Chronic Passive Congestion Images]
+* [{{SERVER}}/library/index.php?/tags/672-chronic_passive_congestion PEIR Digital Library: Chronic Passive Congestion Images]
 * [http://library.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html#1 Webpath: Hepatic Pathology]

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 * <spoiler text="What is the most common cause of chronic passive congestion of the liver?">Right-sided heart failure. Also, obstruction of the inferior vena cava or hepatic vein (usually associated with neoplasia and/or a hypercoagulable state leading to thrombosis) can cause hepatic congestion</spoiler>
 * <spoiler text="Why is the central vein region most severely affected by chronic passive congestion?">The central vein region is farthest away from the arterial (oxygenated) blood so this region has the lowest oxygen tension anyway. With congestion and stasis, this central vein region becomes hypoxic which results in liver cell atrophy and necrosis. The peripheral regions are hypoxic but and develop fatty change. Thus, the dark red, congested, and necrotic central vein region that is surrounded by yellow fatty change gives the morphology that is termed "nutmeg liver."</spoiler>
 {{IPLab 4}}
 [[Category: IPLab:Lab 4]]

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 == Autopsy Findings ==
-At autopsy the lungs were congested and edematous with evidence of lobar pneumonia. The heart weighed 540 grams and showed 75 to 95% atherosclerotic stenosis of all the major coronary arteries. The right and left ventricles were markedly dilated. The ventricular walls were extremely thin with patchy areas of subendocardial fibrosis. The liver weighed 1630 grams and displayed the classic "nutmeg appearance" of chronic passive hepatic congestion on cut surface. == Images ==
+At autopsy the lungs were congested and edematous with evidence of lobar pneumonia. The heart weighed 540 grams and showed 75 to 95% atherosclerotic stenosis of all the major coronary arteries. The right and left ventricles were markedly dilated. The ventricular walls were extremely thin with patchy areas of subendocardial fibrosis. The liver weighed 1630 grams and displayed the classic "nutmeg appearance" of chronic passive hepatic congestion on cut surface.
 <gallery heights="250px" widths="250px">
 File:IPLab4ChronicPassiveCongestion1.jpg|This is a gross photograph of a liver demonstrating chronic passive congestion. Note the accentuation of the centrilobular pattern evidenced by the dark-brown-staining areas in this tissue.

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 File:IPLab4ChronicPassiveCongestion9.jpg|This is a gross photograph of the cut surface of a liver with chronic passive congestion (left) compared to the cut surface of a nutmeg (right).
 </gallery>
 == Study Questions ==