IPLab:Lab 6:Acute Rejection - Revision history

Seung Park at 16:19, 3 January 2014

2014-01-03T16:19:50Z

2013-08-30T01:36:16Z

‎Images

2013-08-23T04:00:13Z

‎Reference

2013-08-23T03:56:36Z

‎Related IPLab Cases

2013-08-23T03:55:40Z

‎Images

2013-08-23T03:54:24Z

‎Journal Articles

2013-08-23T03:53:41Z

2013-08-23T03:49:17Z

2013-08-21T15:38:50Z

2013-08-21T14:28:06Z

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 File:IPLab6AcuteRejection10.jpg|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium and cells within the renal tubules.
 </gallery>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
+* [{{SERVER}}/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
 * [http://library.med.utah.edu/WebPath/IMMHTML/IMMIDX.html#4 WebPath: Transplant Rejection]

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 * [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]
 * [http://emedicine.medscape.com/article/430128-overview eMedicine Medical Library: Renal Transplantation]
-* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: Nephritic Syndrome]
+* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: Nephrotic Syndrome]
 * [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_failure/chronic_kidney_disease.html Merck Manual: Chronic Kidney Disease]
 * [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_replacement_therapy/hemodialysis.html Merck Manual: Hemodialysis]

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 == Related IPLab Cases ==
+* [[IPLab:Lab 1:Kidney Infarction|Lab 1: Kidney: Infarction (Coagulative Necrosis)]]
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]

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 === Images ===
+* [http://peir.path.uab.edu/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
 == Related IPLab Cases ==

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 === Journal Articles ===
+* Matas AJ.  [http://www.ncbi.nlm.nih.gov/pubmed/11272615 Impact of acute rejection on development of chronic rejection in pediatric renal transplant recipients].  ''Pediatr Transplant'' 2000 May;4(2):92-9.
 === Images ===

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]
 === Journal Articles ===

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 * <spoiler text="What cells make up the interstitial infiltrate seen in this case of acute transplant rejection?">Mononuclear cells - primarily CD4+ and CD8+ lymphocytes.</spoiler>
 * <spoiler text="What is the cellular response seen in the acute rejection vasculitis in this case of acute transplant rejection?">Neutrophils are recruited to the lesions due to immunoglobulin deposition and complement fixation. There is also deposition of fibrin and thrombosis.</spoiler>
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]

← Older revision		Revision as of 14:28, 21 August 2013
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		+	== Clinical Summary ==
		+	This 34-year-old white male with end-stage chronic glomerulonephritis had been receiving hemodialysis three times per week for 4 months when he was admitted to the hospital for a living related-donor transplantation from his mother. Other than the kidney disease, the patient was in good health. The transplant was performed successfully with no complications. However, eight days later, transplant rejection necessitated returning the patient to the operating room for a nephrectomy of the transplanted kidney. After the nephrectomy, the patient did quite well, was returned to hemodialysis, and was discharged home in good condition.
		+
		+	== Autopsy Findings ==
		+	The kidney weighed 240 grams and was edematous. The capsule stripped with ease to reveal a pale tan-brown cortex which was irregularly red-mottled. Upon sectioning, the cortical band was ill-defined, and the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis displayed generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.
		+
	== Images ==		== Images ==
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">