IPLab:Lab 6:Glomerulonephritis - Revision history

Seung Park at 16:19, 3 January 2014

2014-01-03T16:19:35Z

Seung Park: /* Images */

2013-08-30T01:36:05Z

‎Images

Seung Park: /* Related IPLab Cases */

2013-08-23T00:48:15Z

‎Related IPLab Cases

Seung Park: /* Images */

2013-08-23T00:47:49Z

‎Images

Seung Park: /* Images */

2013-08-23T00:47:15Z

‎Images

Seung Park: /* Journal Articles */

2013-08-23T00:44:25Z

‎Journal Articles

Seung Park at 00:43, 23 August 2013

2013-08-23T00:43:31Z

Peter Anderson at 15:36, 21 August 2013

2013-08-21T15:36:52Z

Seung Park at 14:26, 21 August 2013

2013-08-21T14:26:21Z

Seung Park at 14:25, 21 August 2013

2013-08-21T14:25:52Z

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 File:IPLab6GN10.jpg|For comparison this is an immunofluorescent photomicrograph of a glomerulus from a patient with Goodpasture's syndrome. The linear (arrows) immunofluorescence is characteristic of Goodpasture's syndrome.
 </gallery>
 == Study Questions ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/226-glomerulonephritis PEIR Digital Library: Glomerulonephritis Images]
+* [{{SERVER}}/library/index.php?/tags/226-glomerulonephritis PEIR Digital Library: Glomerulonephritis Images]
 * [http://library.med.utah.edu/WebPath/RENAHTML/RENALIDX.html#8 WebPath: Glomerulonephritis]

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 == Related IPLab Cases ==
+* [[IPLab:Lab 1:Kidney Infarction|Lab 1: Kidney: Infarction (Coagulative Necrosis)]]
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]

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 === Images ===
 * [http://peir.path.uab.edu/library/index.php?/tags/226-glomerulonephritis PEIR Digital Library: Glomerulonephritis Images]
 == Related IPLab Cases ==

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 === Images ===
+* [http://peir.path.uab.edu/library/index.php?/tags/226-glomerulonephritis PEIR Digital Library: Glomerulonephritis Images]
 == Related IPLab Cases ==

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 === Journal Articles ===
+* Lan HY, Yang N, Nikolic-Paterson DJ, Yu XQ, Mu W, Isbel NM, Metz CN, Bucala R, Atkins RC.  [http://www.ncbi.nlm.nih.gov/pubmed/10652026 Expression of macrophage migration inhibitory factor in human glomerulonephritis].  ''Kidney Int'' 2000 Feb;57(2):499-509.
 === Images ===

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 * <spoiler text="What is the pathogenetic mechanism of poststreptococcal glomerulonephritis?">Patients have elevated antibody titers to streptococcal antigens, decreased complement levels, and accumulations of immune complexes and complement in the glomeruli suggesting immune complex mediated glomerular injury. Some streptococcal antigens (endostreptosin and several cationic antigens) have been demonstrated on the glomerular basement membrane. Thus, it is not known for sure if the glomerular damage is caused by circulating antigen antibody complexes, antibodies attacking streptococcal antigens that are attached to the basement membrane, or a combination of both processes. In any event, antibodies bind to antigens, activate complement, and cause damage to the glomeruli.
 </spoiler>
 {{IPLab 6}}
 [[Category: IPLab:Lab 6]]

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 == Clinical Summary ==
-During the course of a routine physical examination two months prior to admission, this 57-year-old white male was noted to have a lesion in the upper lobe of the right lung. Initially, he was treated for two weeks with ampicillin. He was then admitted to an outside hospital for further study. All studies including sputum studies for tubercle bacilli, bronchial washings, and bronchoscopy were negative and he was discharged. Review of systems revealed the presence of mild dyspnea on exertion, accompanied by a slightly productive cough. Of interest was the fact that the patient had been PPD positive for the past 4 to 5 years, but this had never been evaluated. On this hospital admission, physical and laboratory examinations were negative. Radiographic examination of the chest revealed a 2 x 2-cm density in the right lower lung field. Several small cavities were identified in this area on CT scan.
+This 17-year-old white male had end-stage renal disease requiring hemodialysis for 10 years. For the previous four years he had hypertension which slowly increased to about 180/120 mm Hg. Laboratory findings included a greatly elevated BUN and creatinine. He was admitted for bilateral nephrectomy and discharged in satisfactory condition on the 10th postoperative day. He was to be contacted in the future for transplantation.
 == Autopsy Findings ==
-The patient underwent a thoracotomy, at which time a portion of the upper lobe of the right lung was removed. Examination of the cut surface revealed small white nodules measuring up to 0.2 cm in diameter.
+The left (97 grams) and right (88 grams) kidneys were of similar appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.
 == Images ==

← Older revision		Revision as of 14:25, 21 August 2013
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		+	== Clinical Summary ==
		+	During the course of a routine physical examination two months prior to admission, this 57-year-old white male was noted to have a lesion in the upper lobe of the right lung. Initially, he was treated for two weeks with ampicillin. He was then admitted to an outside hospital for further study. All studies including sputum studies for tubercle bacilli, bronchial washings, and bronchoscopy were negative and he was discharged. Review of systems revealed the presence of mild dyspnea on exertion, accompanied by a slightly productive cough. Of interest was the fact that the patient had been PPD positive for the past 4 to 5 years, but this had never been evaluated. On this hospital admission, physical and laboratory examinations were negative. Radiographic examination of the chest revealed a 2 x 2-cm density in the right lower lung field. Several small cavities were identified in this area on CT scan.
		+
		+	== Autopsy Findings ==
		+	The patient underwent a thoracotomy, at which time a portion of the upper lobe of the right lung was removed. Examination of the cut surface revealed small white nodules measuring up to 0.2 cm in diameter.
		+
	== Images ==		== Images ==
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">