IPLab:Lab 7:Malignant Melanoma - Revision history

Peter Anderson: /* Journal Articles */

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‎Journal Articles

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‎Journal Articles

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‎Journal Articles

2014-01-03T16:25:06Z

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‎Images

2013-08-23T19:49:55Z

‎Related IPLab Cases

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‎Images

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‎Journal Articles

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‎Reference

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 === Journal Articles ===
 * Banerjee SS, Harris M.  [http://www.ncbi.nlm.nih.gov/pubmed/10792480 Morphological and immunophenotypic variations in malignant melanoma].  ''Histopathology'' 2000 May;36(5):387-402.
-* Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D’Arrigo C, Robson A, and Bastian BC.[http://https://www.nejm.org/doi/pdf/10.1056/NEJMoa1502583 The Genetic Evolution of Melanoma from Precursor Lesions].  ''New England Journal of Medicine'' 2015 Nov;373:1926-1936.
+* Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D’Arrigo C, Robson A, and Bastian BC.[http://www.nejm.org/doi/pdf/10.1056/NEJMoa1502583 The Genetic Evolution of Melanoma from Precursor Lesions].  ''New England Journal of Medicine'' 2015 Nov;373:1926-1936.
 === Images ===

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 === Journal Articles ===
 * Banerjee SS, Harris M.  [http://www.ncbi.nlm.nih.gov/pubmed/10792480 Morphological and immunophenotypic variations in malignant melanoma].  ''Histopathology'' 2000 May;36(5):387-402.
-* Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D’Arrigo C, Robson A, and Bastian BC.[http://http://www.nejm.org/doi/pdf/10.1056/NEJMoa1502583 The Genetic Evolution of Melanoma from Precursor Lesions].  ''New England Journal of Medicine'' 2015 Nov;373:1926-1936.
+* Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D’Arrigo C, Robson A, and Bastian BC.[http://https://www.nejm.org/doi/pdf/10.1056/NEJMoa1502583 The Genetic Evolution of Melanoma from Precursor Lesions].  ''New England Journal of Medicine'' 2015 Nov;373:1926-1936.
 === Images ===

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 === Journal Articles ===
 * Banerjee SS, Harris M.  [http://www.ncbi.nlm.nih.gov/pubmed/10792480 Morphological and immunophenotypic variations in malignant melanoma].  ''Histopathology'' 2000 May;36(5):387-402.
 === Images ===

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 File:IPLab7Melanoma8.jpg|This is a high-power photomicrograph of the main tumor mass showing the cellular details. The individual melanoma cells contain large nuclei with irregular contours having chromatin clumped at the periphery of the nuclear membrane and prominent red (eosinophilic) nucleoli.
 </gallery>
 == Study Question ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/2148-melanoma PEIR Digital Library: Melanoma Images]
+* [{{SERVER}}/library/index.php?/tags/2148-melanoma PEIR Digital Library: Melanoma Images]
 * [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html WebPath: Neoplasia]

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 * [http://peir.path.uab.edu/library/index.php?/tags/2148-melanoma PEIR Digital Library: Melanoma Images]
 * [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html WebPath: Neoplasia]
 {{IPLab 7}}
 [[Category: IPLab:Lab 7]]

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/1100753-overview eMedicine Medical Library: Cutaneous Melanoma]
 === Journal Articles ===

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 * <spoiler text="What are risk factors for developing melanoma?">Sunlight appears to play an important role in the development of skin malignant melanoma. Lightly pigmented individuals are at higher risk for the development of melanoma than darkly pigmented individuals. Sunlight does not seem to be the only predisposing factor, and the presence of a pre-existing nevus (e.g., a dysplastic nevus), hereditary factors, or even exposure to certain carcinogens may play a role in lesion development and evolution.</spoiler>
 * <spoiler text="What role may tumor specific antigens play in development of malignant melanoma?">Approximately 40% of human melanomas express a tumor specific antigen referred to as melanoma antigen-1 (MAGE-1). Molecular analysis has revealed that the gene encoding MAGE-1 is present in normal cells as well as in tumor cells, and there is no evidence that it is mutated in cancer cells. However, as has been seen in some animal tumors, the gene is silent in normal adult cells; whether or not it is expressed during development remains to be determined. CD8+ cytotoxic T cells specific for MAGE-1 can be obtained by culturing tumor cells with patients’ lymphocytes in vitro.</spoiler>
 {{IPLab 7}}
 [[Category: IPLab:Lab 7]]