IPLab:Lab 7:Osteosarcoma - Revision history

Seung Park at 16:26, 3 January 2014

2014-01-03T16:26:57Z

2013-08-30T01:41:28Z

‎Images

2013-08-23T20:09:57Z

‎Related IPLab Cases

2013-08-23T20:09:42Z

‎Images

2013-08-23T20:08:45Z

‎Images

2013-08-23T20:06:58Z

‎Journal Articles

2013-08-23T20:05:25Z

‎Reference

2013-08-23T04:22:03Z

2013-08-21T15:41:45Z

2013-08-21T14:36:03Z

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 File:IPLab7Osteosarcoma15.jpg|This is a high-power photomicrograph of the tumor demonstrating the anaplastic cell morphology and multiple mitotic figures (arrows).
 </gallery>
 == Study Question ==

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 === Images ===
-* [http://peir.path.uab.edu/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
+* [{{SERVER}}/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
 * [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html#5 WebPath: Malignant Neoplasms -- Examples of Sarcomas]

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 * [http://peir.path.uab.edu/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
 * [http://library.med.utah.edu/WebPath/NEOHTML/NEOPLIDX.html#5 WebPath: Malignant Neoplasms -- Examples of Sarcomas]
 {{IPLab 7}}
 [[Category: IPLab:Lab 7]]

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 === Images ===
 * [http://peir.path.uab.edu/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
 == Related IPLab Cases ==

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 === Images ===
+* [http://peir.path.uab.edu/library/index.php?/tags/797-osteosarcoma PEIR Digital Library: Osteosarcoma Images]
 == Related IPLab Cases ==

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 === Journal Articles ===
+* Wittig JC, Bickels J, Priebat D, Jelinek J, Kellar-Graney K, Shmookler B, Malawer MM.  [http://www.ncbi.nlm.nih.gov/pubmed/11925089 Osteosarcoma: a multidisciplinary approach to diagnosis and treatment].  ''Am Fam Physician'' 2002 Mar 15;65(6):1123-32.
 === Images ===

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 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/988516-overview eMedicine Medical Library: Pediatric Osteosarcoma]
 === Journal Articles ===

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 * <spoiler text="What are some of the risk factors associated with the pathogenesis of osteosarcoma?">Gene mutations are fundamental to the development of osteosarcoma. Patients with hereditary retinoblastomas have a several hundred-fold greater risk of developing osteosarcoma. Mutations in the p53 suppressor gene (Li-Fraumeni syndrome) has been implicated in the development of most nonhereditary osteosarcomas as well as many other types of cancer. Interestingly, many osteosarcomas develop at sites of greatest bone growth where bone cell mitotic activity is at its peak--e.g., the base of the femoral growth plate where primary spongiosa is being formed and in Pagetic bone with its frenzy of bone formation and resorption.</spoiler>
 * <spoiler text="What is the prognosis for patients with osteosarcoma?">Osteosarcomas are aggressive neoplasms that spread through the bloodstream, and at the time of diagnosis, approximately 20% of patients have demonstrable pulmonary metastases. In those who die of the neoplasm, 90% have metastases to the lungs, bones, brain, and elsewhere. With current treatment regimens the long-term survival rate has been increased to approximately 60% from the historic controls of 25%.</spoiler>
 {{IPLab 7}}
 [[Category: IPLab:Lab 7]]

← Older revision		Revision as of 14:36, 21 August 2013
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		+	== Clinical Summary ==
		+	This 14-year-old white male first experienced mild pain in the left knee after playing baseball, approximately two months prior to admission. The pain persisted in an intermittent fashion, and was described as being somewhat worse at night. Approximately two weeks prior to admission, the pain increased significantly and was accompanied by marked swelling and loss of considerable motion of the knee joint. These symptoms were accompanied by a history of decreased appetite, lethargy, and a 10-pound weight loss. On physical examination, the left knee was enlarged diffusely, firm, and non-tender. Following biopsy, the patient was subjected to surgical removal of the distal femur and knee with placement of a prosthetic knee joint and bone grafts.
		+
		+	== Autopsy Findings ==
		+	The distal diaphysis of the femur and adjacent soft tissues were involved in a 15 x 10 x 10-cm mass. The cut surface of the mass was fleshy white, with focal areas of hemorrhage.
		+
	== Images ==		== Images ==
	<gallery heights="250px" widths="250px">		<gallery heights="250px" widths="250px">