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File:IPLab12RadiationChanges8.jpg|This high-power photomicrograph of the wall of the ileum shows more examples of pleomorphic cells caused by radiation injury (arrows).
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== Virtual Microscopy ==
<peir-vm>IPLab12RadiationChanges</peir-vm>
== Study Questions ==
* <spoiler text="Why are the small intestine and colon so susceptible to radiation injury?">The gastrointestinal tract is very radiosensitive and is frequently affected in all forms of deep radiation. The intestinal epithelium (crypt cells) are particularly radiosensitive due to their high turnover rate. These cell often show nuclear and cellular pleomorphism, mitotic abnormalities, and cell necrosis. Later, ulcerations may appear, along with vascular and connective tissue changes. The late effects of intestinal injury comprise mucosal and submucosal atrophy and fibrosis, occasionally producing intestinal strictures.</spoiler>
* <spoiler text="Are patients who have been treated with radiation more susceptible to formation of new cancers?">Yes, due to the above-mentioned alterations in nuclear and mitotic activity.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/180084-overview eMedicine Medical Library: Intestinal Radiation Injury]
* [http://emedicine.medscape.com/article/265956-overview eMedicine Medical Library: Radiation Therapy in Gynecology]
* [http://www.merckmanuals.com/professional/injuries_poisoning/radiation_exposure_and_contamination/radiation_exposure_and_contamination.html Merck Manual: Radiation Exposure and Contamination]
=== Journal Articles ===
* Reis ED, Vine AJ, Heimann T. [http://www.ncbi.nlm.nih.gov/pubmed/12780647 Radiation damage to the rectum and anus: pathophysiology, clinical features and surgical implications]. ''Colorectal Dis'' 2002 Jan;4(1):2-12.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/56-radiation PEIR Digital Library: Radiation Images]
* [http://library.med.utah.edu/WebPath/GIHTML/GIIDX.html#5 WebPath: Small Intestine Images]
{{IPLab 12}}
[[Category: IPLab:Lab 12]]