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→Virtual Microscopy
== Clinical Summary ==
This 33-year-old white female was admitted for evaluation of abnormal findings on a chest x-ray. She was asymptomatic and a physical examination revealed no significant abnormalities. Laboratory results indicated hypercalcemia and elevated gamma globulin. Radiographic examination showed enlarged subcarinal, hilar, and right paratracheal lymph nodes. A right paratracheal lymph node was biopsied. Special stains for acid-fast bacilli and fungi were negative and a diagnosis of sarcoidosis was made.
== Images ==
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== Virtual Microscopy ===== Lymph Node: Sarcoidosis ===<peir-vm>IPLab3Sarcoidosis</peir-vm> === Lymph Node ===<peir-vm>UAB-Histology-00035</peir-vm> == Study Questions ==* <spoiler text="What is sarcoidosis?">The exact cause of sarcoidosis is unknown. Sarcoidosis is characterized by non-caseating granulomas in many tissues and organs.</spoiler>* <spoiler text="What is the characteristic phenotype of sarcoid granulomas?">The typical characteristic of a sarcoid granuloma is a non-caseating granuloma which consists of an aggregate of tightly-clustered epitheliod cells, often with Langhans’ or multinucleated giant cells. Occasionally, asteroid bodies may be seen.</spoiler>* <spoiler text="What are asteroid bodies and are they pathognomonic for sarcoid or are they seen in other diseases?">Asteroid bodies are stellate inclusions within giant cells. They are not pathognomonic for sarcoid; they can be seen in other granulomatous disease processes (e.g., berylliosis).</spoiler> == Additional Resources ===== Reference ===* [http://emedicine.medscape.com/article/809047-overview eMedicine Medical Library: Acute Complications of Sarcoidosis]* [http://emedicine.medscape.com/article/301914-overview eMedicine Medical Library: Sarcoidosis]* [http://emedicine.medscape.com/article/1123970-overview eMedicine Medical Library: Dermatologic Manifestations of Sarcoidosis]* [http://emedicine.medscape.com/article/1147324-overview eMedicine Medical Library: Neurosarcoidosis]* [http://www.merckmanuals.com/professional/pulmonary_disorders/sarcoidosis/sarcoidosis.html Merck Manual: Sarcoidosis] === Journal Articles ===* English JC, Patel PJ, Greer KE. [http://www.mdconsult.com/das/article/body/421068364-2/jorg=journal&source=MI&sp=11817316&sid=119276088/N/217466/1.html?issn= Sarcoidosis]. ''J Am Acad Dermatol'' 2001;44:725-43* Johns CJ, Michele TM. [http://www.ncbi.nlm.nih.gov/pubmed/10195091 The clinical management of sarcoidosis. A 50-year experience at the Johns Hopkins Hospital]. ''Medicine (Baltimore)'' 1999 Mar;78(2):65-111. === Images ===* [{{IPLab 3SERVER}}/library/index.php?/tags/531-sarcoidosis PEIR Digital Library: Sarcoidosis Images]* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html#2 WebPath: Granulomatous Disease]
== Related IPLab Cases ==
* [[IPLab:Lab 2:Metastatic Calcification|Lab 2: Lung: Metastatic Calcification]]
{{IPLab 3}}
[[Category: IPLab:Lab 3]]