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== Clinical Summary ==
This 61-year-old female was first admitted to the hospital because of ascites and pedal edema. A liver biopsy revealed a marked intracellular accumulation of iron. The serum iron concentration was reported as 220 mcg/dL. On the basis of these studies, the diagnosis of hemochromatosis was made. It should be noted that the patient also exhibited an abnormal glucose tolerance curve test at this time (following the ingestion of a test dose of glucose, the blood glucose level rose to 290 mg/dL at one hour and remained at this level for the next three hours). Subsequent to the first admission, the patient was admitted on several occasions for ascites. The patient's last admission was necessitated by the development of symptoms and signs of hepatic failure (hepatic coma) characterized by jaundice and coma.
== Autopsy Findings ==
The liver weighed 800 820 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.
== Images ==
File:IPLab5Hemochromatosis11.jpg|This is a histologic section of pancreas from this case stained for iron (Prussian blue). Note the accumulation of iron in the parenchymal cells (1). There is also iron in the pancreatic islets (2).
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== Virtual Microscopy ==
=== H&E ===
===Liver: Hemochromatosis ===
<peir-vm>IPLab5Hemochromatosis_HE</peir-vm>
=== Normal Liver ===
<peir-vm>UAB-Histology-00149</peir-vm>
=== Prussian Blue ===
<peir-vm>IPLab5Hemochromatosis_Prussian_blue</peir-vm>
== Study Questions ==
=== Journal Articles ===
* Powell LW, Seckington RC, Deugnier Y. [http://ac.els-cdn.com/S014067361501315X/1-s2.0-S014067361501315X-main.pdf?_tid=61a0b7de-07d2-11e6-b26f-00000aab0f02&acdnat=1461251264_8f332714107047706b12570ed99cf384 Haemochromatosis]. ''Lancet'' 2016.
* Ayonrinde OT, Milward EA, Chua AC, Trinder D, Olynyk JK. [http://www.ncbi.nlm.nih.gov/pubmed/18712630 Clinical perspectives on hereditary hemochromatosis]. ''Crit Rev Clin Lab Sci'' 2008;45(5):451-84.
* Bassett ML. [http://www.ncbi.nlm.nih.gov/pubmed/11456037 Haemochromatosis: iron still matters]. ''Intern Med J'' 2001 May-Jun;31(4):237-42.
=== Images ===
* [http://peir.path.uab.edu{{SERVER}}/library/index.php?/tags/177-hemochromatosis PEIR Digital Library: Hemochromatosis Images]
* [http://library.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html#3 WebPath: Hepatic Pigmentary Disorders]
* [http://library.med.utah.edu/WebPath/CINJHTML/CINJIDX.html#5 WebPath: Cellular Accumulations]