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File:IPLab3Tuberculosis5.jpg|This high-power photomicrograph of a tuberculosis granuloma demonstrates acid-fast bacilli (arrows).
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== Virtual Microscopy ==
=== Lung: Tuberculosis H&E ===
<peir-vm>IPLab3Tuberculosis_HE</peir-vm>
=== Lung: Tuberculosis AFGT ===
<peir-vm>IPLab3Tuberculosis_AFGT</peir-vm>
=== Normal Lung ===
<peir-vm>UAB-Histology-00107</peir-vm>
== Study Questions ==
* <spoiler text="Does everyone with a positive PPD test have TB?">No, it just indicates exposure to a ''Mycobacterium'' species, many of which are non-pathogenic in humans. Those who have received Bacillus Calmette–Guérin (BCG) vaccination, for instance, routinely have a positive PPD test even though they have never been exposed to ''Mycobacterium tuberculosis''.</spoiler>
* <spoiler text="How does this lesion differ from the lesions seen in sarcoid?">These are caseating granulomas with a central region of caseation necrosis and macrophages and lymphocytes around the periphery. Multinucleated, primarily Langhans’ type, giant cells are present within these nodules.</spoiler>
* <spoiler text="What are epithelioid cells?">Epitheliod cells are tissue macrophages that have an epithelium-like appearance.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/230802-overview eMedicine Medical Library: Tuberculosis]
* [http://www.merckmanuals.com/professional/infectious_diseases/mycobacteria/tuberculosis_tb.html Merck Manual: Tuberculosis]
=== Journal Articles ===
* Rodrigues DS, Medeiros EA, Weckx LY, Bonnez W, Salomão R, Kallas EG. [http://www.ncbi.nlm.nih.gov/pubmed/11982602 Immunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculosis infection and disease]. ''Clin Exp Immunol'' 2002 Apr;128(1):149-54.
* Horsburgh CR, Barry CE, Lange C. [http://www.nejm.org/doi/full/10.1056/NEJMra1413919 Treatment of Tuberculosis]. ''NEJM'' 2015 Nov 26;373:2149-2160.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/259-tuberculosis PEIR Digital Library: Tuberculosis]
* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html#4 WebPath: Granulomatous Lung Disease]
== Related IPLab Cases ==
* [[IPLab:Lab 1:Tuberculosis|Lab 1: Lung: Tuberculosis (Caseous Necrosis)]]
* [[IPLab:Lab 6:Tuberculosis|Lab 6: Lung: Tuberculosis]]
{{IPLab 3}}
[[Category: IPLab:Lab 3]]