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File:IPLab6GravesDisease7.jpg|Closer view of cut surface of the thyroid with nodular goiter. Note the multilobular appearance of the tissue.
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== Virtual Microscopy ==
<peir-vm>IPLab6GravesDisease</peir-vm>
== Study Questions ==
* <spoiler text="What is the immunologic mechanism responsible for Graves' disease?">Autoantibodies directed towards the TSH receptor of the thyroid cause stimulation of the thyroid leading to increased secretion of thyroid hormones and growth of the thyroid gland.</spoiler>
* <spoiler text="What role does genetics play in the predisposition to Graves' disease?">* Graves' disease is more common in females than males
* It has been linked to HLA-B8 and DR3 in whites but different haplotypes in Asians
* It has a familial predisposition
* It is more common in patients with other forms of autoimmune thyroid problems (e.g., Hashimoto's thyroiditis)</spoiler>
* <spoiler text="Does Graves' disease predispose to thyroid cancer?">There is little evidence to suggest an increased frequency of thyroid cancer in patients with Graves' disease.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/920283-overview eMedicine Medical Library: Pediatric Graves Disease]
* [http://emedicine.medscape.com/article/767130-overview eMedicine Medical Library: Hyperthyroidism, Thyroid Storm, and Graves Disease]
* [http://emedicine.medscape.com/article/120034-overview eMedicine Medical Library: Goiter]
* [http://emedicine.medscape.com/article/120140-overview eMedicine Medical Library: Diffuse Toxic Goiter]
* [http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/thyroid_disorders/overview_of_thyroid_function.html Merck Manual: Overview of Thyroid Function]
* [http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/thyroid_disorders/hyperthyroidism.html Merck Manual: Hyperthyroidism]
=== Journal Articles ===
* Smith TJ and Hegedüs L. [http://www.nejm.org/doi/full/10.1056/NEJMra1510030 Graves’ Disease]. NEJM 2016 375:1552-1565.
* Fraser T, Green D. [http://www.ncbi.nlm.nih.gov/pubmed/11554873 Weathering the storm: beta-blockade and the potential for disaster in severe hyperthyroidism]. ''Emerg Med (Fremantle)'' 2001 Sep;13(3):376-80.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/15-endocrine/140-thyroid/651-autoimmune_thyroiditis PEIR Digital Library: Autoimmune Thyroiditis Images]
* [http://library.med.utah.edu/WebPath/ENDOHTML/ENDOIDX.html Webpath: Endocrine Pathology]
== Related IPLab Cases ==
* [[IPLab:Lab 6:Hashimoto's Thyroiditis|Lab 6: Thyroid: Hashimoto's Thyroiditis]]
* [[IPLab:Lab 7:Adenoma|Lab 7: Thyroid: Adenoma]]
{{IPLab 6}}
[[Category: IPLab:Lab 6]]