User contributions
20 August 2013
IPLab:Lab 6:Hashimoto's Thyroiditis
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+27
IPLab:Lab 6:Hashimoto's Thyroiditis
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+189
IPLab:Lab 6:Hashimoto's Thyroiditis
Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab6Hashimoto1.jpg| </gallery> {{IPLab 6}} Category: IPLab:Lab 6"
IPLab:Lab 5:Nodular Intercapillary Glomerulosclerosis
Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab5DM1.jpg|This is a gross photograph of the kidneys from this case. Note that there are multiple shrunken region..."
File:IPLab5DM7.jpg
This is a photomicrograph of kidney with a focal exudative lesion in a glomerulus (arrow) and sclerosis, interstitial fibrosis, and congestion.
File:IPLab5DM6.jpg
This is a higher-power photomicrograph of a glomerulus with nodular glomerulosclerosis (arrows). These are the classic Kimmelstiel-Wilson lesions ("K-W lesions") seen in diabetics with nodular glomerulosclerosis.
File:IPLab5DM5.jpg
This is a photomicrograph of a glomerulus with nodular glomerulosclerosis (1). Also note the intertubular fibrosis and the changes in the blood vessels (2).
File:IPLab5DM4.jpg
This is a high-power photomicrograph of two glomeruli with intercapillary glomerulosclerosis (arrows).
File:IPLab5DM3.jpg
This is a higher-power photomicrograph of the cortical region. In this region there is ischemic obsolescence of glomeruli and one glomerulus with nodular glomerulosclerosis (1). Also note the thickened walls of the blood vessels (2).
File:IPLab5DM2.jpg
This is a low-power photomicrograph of the kidney from this patient. The section extends from cortex (1) to the medulla (2).
File:IPLab5DM1.jpg
This is a gross photograph of the kidneys from this case. Note that there are multiple shrunken regions (old infarcts) (arrows) and the kidneys have a rough granular appearance on the surface, which is caused by multiple small infarcts of small vessels...
IPLab:Lab 5:Gout
Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab5Gout1.jpg|This is a gross photograph of an index finger from a patient with gout. The finger has been sectione..."
File:IPLab5Gout8.jpg
This is a gross photograph of a tophus on the great toe of another patient with gout (arrow). The healed surgical incision and the size of this tophus indicate that this was a long-standing problem for this patient.
File:IPLab5Gout7.jpg
This is a photomicrograph of a tophus that was fixed in alcohol prior to histologic processing. The alcohol fixation preserves the water soluble urate crystals within the tissue. Note the urate crystals visible in this photomicrograph (arrows). Also no...
File:IPLab5Gout6.jpg
This is a high-power photomicrograph of the edge of the tophus. The character of the intense chronic inflammatory cell reaction is evident and note the presence of giant cells within this inflammatory cell reaction (arrows).
File:IPLab5Gout5.jpg
This is a higher-power photomicrograph of the edge of the tophus. Most of the urate crystals dissolve away during processing. The inflammatory cells at the edge of these foci are clearly visible (arrow).
File:IPLab5Gout4.jpg
This higher-power photomicrograph of the tophus demonstrates the collections of urate crystals (1) and the inflammatory cells at the edge of these foci (2).
File:IPLab5Gout3.jpg
This is a low-power photomicrograph of the tophus removed from the elbow of this patient. Note the fibrous connective tissue (1) and the large foci containing the urate crystals (2) surrounded by the intense chronic inflammatory reaction.
File:IPLab5Gout2.jpg
This is a gross photograph of the elbow of this patient. The subcutaneous nodules (arrows) on this arm are tophi caused by gout.
File:IPLab5Gout1.jpg
This is a gross photograph of an index finger from a patient with gout. The finger has been sectioned longitudinally to demonstrate the distal interphalangeal joint. Note the white chalky material within and adjacent to the joint (arrows).
IPLab:Lab 5:Gaucher Disease
Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab5Gaucher1.jpg|This is a gross photograph of spleen from this case. The spleen is enlarged and the surface is fi..."
File:IPLab5Gaucher8.jpg
This is a higher-power photomicrograph of the spleen from this case. At this higher power individual cells can be better appreciated and the fibrillar nature of the eosinophilic cytoplasmic material can be seen.
File:IPLab5Gaucher7.jpg
This is another high-power photomicrograph of the spleen from this case. At this high power individual cells can be better appreciated.
File:IPLab5Gaucher6.jpg
This is another high-power photomicrograph of the spleen from this case. At this power it is easier to see the large eosinophilic cells.
File:IPLab5Gaucher5.jpg
This is a higher-power photomicrograph of the spleen from this case. Again there is no white pulp and the red pulp is filled with large eosinophilic cells.
File:IPLab5Gaucher4.jpg
This is a photomicrograph of the spleen from this case. There is very little if any white pulp evident in this section.
File:IPLab5Gaucher3.jpg
This is a low-power photomicrograph of normal spleen (left) and the spleen from this case (right). The loose appearance of the tissue in the Gaucher spleen is due to artifactual loss of tissue during histologic processing.
File:IPLab5Gaucher2.jpg
This is a cut section of spleen from this case. Again note the fine granular appearance to the tissue.
File:IPLab5Gaucher1.jpg
This is a gross photograph of spleen from this case. The spleen is enlarged and the surface is finely granular.
IPLab:Lab 5:Hemochromatosis
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IPLab:Lab 5:Hemochromatosis
Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab5Hemochromatosis1.jpg|This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosi..."
File:IPLab5Hemochromatosis11.jpg
This is a histologic section of pancreas from this case stained for iron (Prussian blue). Note the accumulation of iron in the parenchymal cells (1). There is also iron in the pancreatic islets (2).
File:IPLab5Hemochromatosis10.jpg
This is a histologic section of pancreas from this case. It is difficult to appreciate at this magnification, but there is brown pigment in the pancreatic acinar cells. Note the islets of Langerhans (1).
File:IPLab5Hemochromatosis9.jpg
This is a gross picture of pancreas from this case. Note the brown discoloration of the tissue.
File:IPLab5Hemochromatosis8.jpg
This higher-power view of liver stained with Prussian blue demonstrates the marked accumulation of iron within the parenchymal cells (1) and in the Kupffer cells in the periportal area (2).
File:IPLab5Hemochromatosis7.jpg
This is a low-power view of liver section stained with Prussian blue. Prussian blue reacts with iron in the tissue to give a blue color.
File:IPLab5Hemochromatosis6.jpg
This trichrome stain of liver section demonstrates the increased fibrous connective tissue in this liver. Note that the liver nodules (1) are surrounded by fibrous connective tissue (2).
File:IPLab5Hemochromatosis5.jpg
This higher-power photomicrograph demonstrates the increased fibrosis in the periportal area (1) and the pigment accumulation (2).
File:IPLab5Hemochromatosis4.jpg
This higher-power view of liver from this case demonstrates the nodules and the brown/black pigment within liver parenchymal cells (arrows).
File:IPLab5Hemochromatosis3.jpg
This is a low-power micrograph of liver from this patient. Note the nodularity of the tissue (arrows).
File:IPLab5Hemochromatosis2.jpg
This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown. Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic).
File:IPLab5Hemochromatosis1.jpg
This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosis. Note that both of these organs have a dark brown coloration.
19 August 2013
IPLab:Lab 5:α1 Antitrypsin Deficiency
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+1,224
File:IPLab5Antitrypsin12.jpg
This is a high-power photomicrograph of liver stained with periodic-acid Schiff's (PAS) stain. This demonstrates the PAS-positive granules of defective alpha 1-antitrypsin that accumulate in the Golgi of hepatocytes (arrows).
File:IPLab5Antitrypsin11.jpg
This is a higher-power photomicrograph of a trichrome-stained section of liver. This section demonstrates the fibrosis (blue material) and the fatty change (arrows).
File:IPLab5Antitrypsin10.jpg
This is a low-power photomicrograph of a trichrome-stained section of liver. There is bridging fibrosis (blue material) between portal regions.
File:IPLab5Antitrypsin9.jpg
This is a low-power photomicrograph of an H&E-stained section of liver. There are increased numbers of inflammatory cells in the periportal region (arrow) and the central vein areas are pale.
File:IPLab5Antitrypsin8.jpg
This is a closer view of the cut section of liver from this case. There is a definite micronodular pattern to the liver parenchyma.
File:IPLab5Antitrypsin7.jpg
This is a gross photograph of the cut section of liver from this case. In this view the liver looks smaller than normal and there is a definite micronodular appearance.
File:IPLab5Antitrypsin6.jpg
This is a gross photograph of the liver from this case. The capsule is somewhat thickened and the surface is slightly roughened, though it is difficult to appreciate the nodularity of the liver.