Clinical Summary
This 52-year-old female had been bitten by a dog two months previously. One week prior to death, she developed severe headache, restlessness, and dysphagia. These symptoms were followed by the appearance of fever, tremor, and general rigidity. The patient was admitted, but expired on the second hospital day.
Images
This is a low-power photomicrograph of the hippocampus (arrow) from this case.
This is a medium-power photomicrograph of brain tissue exhibiting edema and evidence of shrunken, necrotic neurons (arrows).
This is a higher-power photomicrograph of the shrunken neurons. One neuron appears to have an eosinophilic intracytoplasmic inclusion body (arrow).
This is a high-power photomicrograph of neurons containing variably-sized intracytoplasmic eosinophilic inclusion bodies (arrows).
This is a high-power photomicrograph of a neuron surrounded by inflammatory cells (lymphocytes and microglia). This neuron has two intracytoplasmic eosinophilic inclusion bodies (arrows).
