Cytologically Yours: Unknowns: 201312: Case 5

Contents

Clinical History

80 year old female. Right breast mass FNA.

Cytology

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Resident Questions

• Diagnosis?

• Cytology diagnosis: Adenocarcinoma.
• Surgical diagnosis: Infiltrating ductal carcinoma

Surgical Pathology

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Cytologic Features

• Disorganized clusters
• Small, crowded groups
• Loss of cohesion
• Nuclear atypia
• Nuclei > 2 x size of RBC
• Conspicuous nucleoli
• Intracytoplasmic lumens
• Absence of myoepithelial cells within groups
• Absence of bipolar nuclei in the background