* <spoiler text="What material is found within these sclerotic nodules and what happens to these lesions over time?">The Kimmelstiel-Wilson (K-W) lesions are ovoid or spherical, often laminated, hyaline masses situated in the periphery of the glomerulus. They are usually within the mesangium of the glomeruli. The nodules are composed of lipids and fibrin. As the disease progresses the K-W nodules enlarge until they compress and obliterate the glomerular tuft. Because of these glomerular and arteriolar lesions, the blood flow to the kidney is compromised and the kidney becomes ischemic. This results in tubular atrophy and interstitial fibrosis and leads to a roughened renal cortical surface.</spoiler>

* <spoiler text="What percent of diabetics develop this lesion and what are the functional consequences?">Approximately 15-30% of long term diabetics develop K-W lesions and in most instances it is associated with renal failure.</spoiler>

{{IPLab 5}}

[[Category: IPLab:Lab 5]]