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File:IPLab6AcuteRejection10.jpg|This high-power photomicrograph demonstrates the cellular infiltrate within the interstitium and cells within the renal tubules.
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== Virtual Microscopy ==
<peir-vm>IPLab6AcuteRejection</peir-vm>
== Study Questions ==
* <spoiler text="What cells make up the interstitial infiltrate seen in this case of acute transplant rejection?">Mononuclear cells - primarily CD4+ and CD8+ lymphocytes.</spoiler>
* <spoiler text="What is the cellular response seen in the acute rejection vasculitis in this case of acute transplant rejection?">Neutrophils are recruited to the lesions due to immunoglobulin deposition and complement fixation. There is also deposition of fibrin and thrombosis.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/429314-overview eMedicine Medical Library: Assessment and Management of the Renal Transplant Patient]
* [http://emedicine.medscape.com/article/430128-overview eMedicine Medical Library: Renal Transplantation]
* [http://www.merckmanuals.com/professional/genitourinary_disorders/glomerular_disorders/nephrotic_syndrome.html Merck Manual: Nephrotic Syndrome]
* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_failure/chronic_kidney_disease.html Merck Manual: Chronic Kidney Disease]
* [http://www.merckmanuals.com/professional/genitourinary_disorders/renal_replacement_therapy/hemodialysis.html Merck Manual: Hemodialysis]
* [http://www.merckmanuals.com/professional/immunology_allergic_disorders/transplantation/kidney_transplantation.html Merck Manual: Kidney Transplantation]
=== Journal Articles ===
* Matas AJ. [http://www.ncbi.nlm.nih.gov/pubmed/11272615 Impact of acute rejection on development of chronic rejection in pediatric renal transplant recipients]. ''Pediatr Transplant'' 2000 May;4(2):92-9.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/2146-rejection PEIR Digital Library: Rejection Images]
* [http://library.med.utah.edu/WebPath/IMMHTML/IMMIDX.html#4 WebPath: Transplant Rejection]
== Related IPLab Cases ==
* [[IPLab:Lab 1:Kidney Infarction|Lab 1: Kidney: Infarction (Coagulative Necrosis)]]
* [[IPLab:Lab 6:Chronic Rejection|Lab 6: Kidney: Chronic Transplant Rejection]]
* [[IPLab:Lab 10:Candidiasis|Lab 10: Kidney: Candidiasis]]
{{IPLab 6}}
[[Category: IPLab:Lab 6]]
