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File:IPLab6Hashimoto9.jpg|This high-power photomicrograph shows more clearly the lymphocytes and plasma cells surrounding the thyroid gland epithelium. Large, eosinophilic, degenerating thyroid gland cells (Hurthle cells) can be seen in this section (arrows).
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== Study Questions ==
* <spoiler text="What signs and symptoms in this patient suggest a diagnosis of hypothyroidism and what are some of the other signs and symptoms seen with hypothyroidism?">Fatigue, lethargy, slowed speech, cold intolerance, dry skin, course hair, puffy face, myxedema, slowed reflexes, and diffuse goiter.</spoiler>
* <spoiler text="What is the pathogenesis of Hashimoto’s thyroiditis and how does this disease differ from Grave’s disease or nutritional goiter?">Hashimoto's thyroiditis is characterized by Iymphocytic infiltration of the thyroid gland and production of antibodies that recognize thyroid-specific antigens. It is currently thought that the disease is caused by abnormal suppressor T-lymphocyte function which results in a localized cell-mediated immune response directed toward the thyroid parenchymal cells. The pathogenesis is not completely understood. In contrast Graves' disease is caused by production of antibodies that mimic the action of thyroid-stimulating hormone. Nutritional goiter is caused by iodine deficiency.</spoiler>
* <spoiler text="What are some of the pathologic changes seen in Hashimoto's thyroiditis?">The gland is usually diffusely enlarged, firm, and slightly lobular. The capsule is intact, and the cut surface is light tan and has a slight lobular pattern. Microscopically there is massive infiltration of the thyroid gland by lymphocytes and plasma cells. Germinal centers can often be seen in the gland. Thyroid follicles are usually absent and the few remaining follicles are devoid of colloid.</spoiler>
{{IPLab 6}}
[[Category: IPLab:Lab 6]]
